Synthetic Studies on Leinamycin. A Synthesis of the 1-Oxo-1,2-dithiolan-3-one Moiety

DOI: 10.1016/0040-4039(92)89010-A

Source and publish data:

Tetrahedron Letters p. 5701 - 5704 (1992)

Update date:2022-07-29

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Authors:

Kanda, Yutaka

Saito, Hiromitsu

Fukuyama, Tohru

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Article abstract of DOI:10.1016/0040-4039(92)89010-A

A synthesis of the 1-oxo-1,2-dithiolan-3-one moiety of antitumor antibiotic leinamycin (1) i described.An intramolecular delivery of a sulfur atom (7 to 8) and a facile Beckmann fragmentation (10 to 12) constitute the backbone of our synthesis.

Full text of DOI:10.1016/0040-4039(92)89010-A

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