Tetrahedron Asymmetry p. 1213 - 1221 (1992)
Update date:2022-09-26
Topics: Synthesis Enantiomer Chirality Homochiral Racemic mixture Glutamic acid
Herdeis, C.
Hubmann, H. P.
A streoselective synthesis of R-Baclofen is presented starting from S-pyroglutamic acid derivative 3.The key steps are the 1,4-conjugate addition of Grignard cuprate (p-ClPh)2CuMgCl to 3 and Barton-Decarboxylation of 6e to 7e.
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Doi:10.1039/c3cc43216e
(2013)Doi:10.1016/S0020-1693(00)92368-5
(1992)Doi:10.1021/acs.joc.7b03198
(2018)Doi:10.1016/j.bmcl.2017.01.084
(2017)Doi:10.1016/S0020-1693(00)92345-4
(1992)Doi:10.1002/chem.201204364
(2013)
