Asymmetric induction in Manganese(III)-based oxidative free-radical cyclizations of chiral esters and amides

Article abstract of DOI:10.1016/S0040-4039(00)61089-4

Mn(III)-based oxidative free-radical cyclizations of phenylmenthyl acetoacetate 1d affords 90% of 11 with 86% de. trans-2-Phenylcyclohexyl ester 1e affords 5e with only 60% de. The 2,5-dimethylpyrrolidine amide 1h affords 14 with higher de (92%), but in only 28% yield.