Synthesis of Derivatives of FK 506 and FR 900520: Modifications at the Binding Domain

DOI: 10.1016/S0040-4020(01)90178-4

Source and publish data:

Tetrahedron p. 5861 - 5874 (1992)

Update date:2022-08-04

Topics:

Authors:

Emmer, Gerhard

Weber-Roth, Sabine

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Article abstract of DOI:10.1016/S0040-4020(01)90178-4

The synthesis of 9-deoxo-FK 506 (13a), 9-deoxo-FR 900520 (13b), 9-deoxo-10(R)-deoxy-FR900520 (14) and its 10(S) isomer 15 is described.Radical deoxygenation/elimination of the 9-dihydro-9,10-thiocarbonates 5a,5b,6a and 6b gave the 9,10 unsaturated compoun

Full text of DOI:10.1016/S0040-4020(01)90178-4

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