An improved synthesis of 24,24-difluoro-1α,25-dihydroxy-vitamin D3 from vitamin D2

DOI: 10.1248/cpb.40.1662

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1662 - 1664 (1992)

Update date:2022-08-04

Topics: Synthesis Chemical reactions Experimental

Authors:

Ando Ando

Kondo Kondo

Koike Koike

Takayama

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.1662

An improved synthesis of a highly potent vitamin D₃ analog, 24,24-difluoro-1α,25-dihydroxyvitamin D₃ has been accomplished. The total yield was 9.3% from inexpensive vitamin D₂ in 11 steps.

Full text of DOI:10.1248/cpb.40.1662

NII-Electronic Library Service

Products guided by the article

Product name:(R)-5-{(R)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2-oxo-hexanoic acid methyl ester

Cas No:144907-43-7

R&D Labs maybe for 144907-43-7

Fusilin chemical science & technology co., ltd.

Contact:532-80698166/86057573, +86-400-669-7885

Address:School of Material Science & Engineering, Shandong Uinversity of Science & Technology, Huangdao Zone, Qindao, Shandong
SICHUAN TONGSHENG AMINOACID CO.LTD

website:http://www.aminoacid.cc

Contact:86-838-2274206/2850606

Address:Room 1-11-1,No.19 of North TianShan Road,Deyang,Sichuan China
Shanghai Goyic Pharmaceutical&Chemical Co,. Ltd

Contact:+86-021-60275964

Address:No. 528 ruiqing road
Lishui Nanming Chemical Co., Ltd(expird)

Contact:+86-0578-2134101，2697830

Address:No.19 Tongji Road Shuige Industrial zone
Chengdu Green Young Biopharmaceutical INC

Contact:+86-28-85337952

Address:1-B-26,Tianhe Industry Park, No.1480 of Tianfu Road,Chengdu,P.R.China,610000

Relevant to this article

Efficient dynamic kinetic resolution of arylamines with Pd/layered double-hydroxide-dodecyl sulfate anion for racemization

Doi:10.1016/j.tetlet.2013.11.041
(2014)
Studies on annelated [1,4]benzothiazines and [1,5]benzothiazepines, V: Synthesis and biological activity of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine

Doi:10.1002/ardp.19923250909
(1992)
Doi:10.1016/S0040-4020(01)97605-7
(1964)
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib

Doi:10.1021/acs.jmedchem.9b01526
(2020)
Au-catalyzed formation of functionalized quinolines from 2-alkynyl arylazide derivatives

Doi:10.1021/ol4019634
(2013)
A turn-On Fluorescent Sensor for Methylglyoxal

Doi:10.1021/ja406077j
(2013)

Article Doi