An improved synthesis of 24,24-difluoro-1α,25-dihydroxy-vitamin D3 from vitamin D2

DOI: 10.1248/cpb.40.1662

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1662 - 1664 (1992)

Update date:2022-08-04

Topics: Synthesis Chemical reactions Experimental

Authors:

Ando Ando

Kondo Kondo

Koike Koike

Takayama

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Article abstract of DOI:10.1248/cpb.40.1662

An improved synthesis of a highly potent vitamin D₃ analog, 24,24-difluoro-1α,25-dihydroxyvitamin D₃ has been accomplished. The total yield was 9.3% from inexpensive vitamin D₂ in 11 steps.

Full text of DOI:10.1248/cpb.40.1662

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