Synthesis and bioevaluation of novel 4-aminoquinoline-tetrazole derivatives as potent antimalarial agents

DOI: 10.1016/j.ejmech.2013.05.023

Source and publish data:

European Journal of Medicinal Chemistry p. 69 - 81 (2013)

Update date:2022-08-15

Topics:

Authors:

Pandey, Shashi

Agarwal, Pooja

Srivastava, Kumkum

RajaKumar

Puri, Sunil K.

Verma, Pravesh

Saxena Saxena

Sharma, Abhisheak

Lal, Jawahar

Chauhan, Prem M. S.

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Article abstract of DOI:10.1016/j.ejmech.2013.05.023

A series of novel tetrazole derivatives of 4-aminoquinoline were synthesized and screened for their antimalarial activities against both chloroquine-senstive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum as well as for cytotoxicity

Full text of DOI:10.1016/j.ejmech.2013.05.023

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Product name:4-(4-((1-tert-butyl-1H-tetrazol-5-yl)(4-chlorophenyl)methyl)piperazin-1-yl)-7-chloroquinoline

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