Bioorganic and Medicinal Chemistry Letters p. 4896 - 4902 (2013)
Update date:2022-08-03
Topics:
Manvar, Atul
Khedkar, Vijay
Patel, Jignesh
Vora, Vipul
Dodia, Narsinh
Patel, Gautam
Coutinho, Evans
Shah, Anamik
In continuation with our previous work in anti-TB research area, in the present study we have demonstrated the structural diversity of quinolylhydrazides as potent anti-tuberculars. The compound library was synthesized by molecular hybridization approach and tested in vitro against Mycobacterium tuberculosis H37Rv strains. Among the designed conjugates, the most promising molecules were found to exhibit 100% Growth Inhibition (GI) at MIC <6.25 μg/mL. Moreover, several analogs in the designed series were also turned out as excellent anti-tuberculars. To probe the structural characteristics influencing on the SAR, the classification model was generated using a binary QSAR approach termed recursive partitioning (RP) analysis. The significant features outlined by the RP model act as a guide in order to design the 'lead' compound.
View MoreWENZHOU M&C FOREIGN TRADE CO.,LTD.
Contact:+86-577-88862917
Address:No.8 Liming West Road,Wenzhou,zhejiang,China
Contact:86-551-63540590
Address:No 1388 Furong Rd., Hefei, Anhui, China
Contact:86-310-8067016
Address:East Fuhua Road,Tiexi Chemical Industrial Estate,Hebei,China
Hangzhou Dingyan Chem Co., Ltd
website:http://www.dingyanchem.com
Contact:86-571-87157530-8002
Address:RM.1118,NO.1 Building, Baiyun Tower,Jianggan Area, Hangzhou city, China,310004
Hangzhou innopharma technology Co,.Ltd.(expird)
Contact:+86-13388601988
Address:Room845,lixin building, moganshan road, hangzhou, china
Doi:10.1002/hlca.19920750608
(1992)Doi:10.1021/ol401858k
(2013)Doi:10.1002/anie.201205584
(2013)Doi:10.1246/bcsj.65.2866
(1992)Doi:10.1021/jm00047a005
(1994)Doi:10.1002/ejoc.201201467
(2013)