Journal fur Praktische Chemie - Chemiker-Zeitung p. 487 - 490 (1992)
Update date:2022-08-04
Topics:
Hess, U.
Raasch, A.-K.
Schulze, M.
Certain Schiff-bases (2-7) react in acetonitrile (1) at a Hg-cathode in a new electrocatalyzed cyanomethylation method in good yields without sideproducts to β-aminonitriles (2a-7a).The synthesis is initiated by an electrochemical deprotonation of 1 by azomethine-radical anions in catalytical amount to acetonitril anions (B-).During nucleophilic reaction of B- with 2-7 up to its complete consumption, the cyanomethylation synthon B- is regenerated in a cyclic, self-reproducing process.Quantum chemical calculation in context with cyanomethylation product analysis permit mechanistical insights and exact prediction of suitable azomethines and coupling position for B-.
View MoreChengda Pharmaceuticals Co., Ltd.
Contact:+86-573-84601188
Address:hengshan Road 5# in Jiashan, zhejiang
Shifang Taifeng New Flame Retardant Co., Ltd
Contact:02884721008
Address:tingjiang industrial park, hefeng town
Hangzhou Hysen Pharma co.,Ltd.
website:http://www.hysenpharma.cn/
Contact:0086-571-88298791
Address:#701,Gudun Road Hangzhou
Shanghai Standard Biotech Co., Ltd.
Contact:+86-18502101150
Address:Room 103, Building 2nd, NO.720, Cailun Road , Pudong District, Shanghai, China
Yicheng Goto Pharmaceuticals Co.,Ltd.
Contact:+86 710 3423122
Address:5th Floor,East Gate of Building #2,Servo-Industrial Park,1st Qilin Road,Xiangyang,Hubei,China
Doi:10.1002/anie.202003125
(2020)Doi:10.1246/bcsj.65.2668
(1992)Doi:10.1016/j.molcata.2013.12.005
(2014)Doi:10.1016/j.tetasy.2013.07.003
(2013)Doi:10.1055/s-0033-1339195
(2013)Doi:10.1021/ja4073172
(2013)
