95. Design and Synthesis of Potent Macrocyclic Benzolactam Growth Hormone Secretagogues

DOI: 10.1002/hlca.19970800421

Source and publish data:

Helvetica Chimica Acta p. 1244 - 1259 (1997)

Update date:2022-08-04

Topics:

Authors:

DeVita, Robert J.

Frontier, Alison J.

Schoen, William R.

Wyvratt, Matthew J.

Fisher, Michael H.

Cheng, Kang

Chan, Wanda W.-S.

Butler, Bridget S.

Smith, Roy G.

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Article abstract of DOI:10.1002/hlca.19970800421

The synthesis of a variety of potent macrocyclic growth hormone secretagogues, i.e. 5, 9, 12, and 20-22, based on the known lead structure L-692,429 (1) is described. These conformationally constrained growth hormone secretagogues were prepared by joining

Full text of DOI:10.1002/hlca.19970800421

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