Synthesis and antihypertensive activity of 3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1 ,5-benzothiazepin-4(5H)-one (diltiazem) derivatives having substituents at the 8 position

DOI: 10.1248/cpb.40.2055

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2055 - 2061 (1992)

Update date:2022-07-29

Topics:

Authors:

Yanagisawa

Fujimoto

Shimoji Shimoji

Kanazaki

Mizutari

Nishino Nishino

Shiga Shiga

Koike Koike

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.2055

In order to improve the potency and duration of biological actions of diltiazem, a number of 1,5-benzothiazepine derivatives having the substituents at the 8 position were prepared and evaluated for their antihypertensive activity in spontaneously hyperte

Full text of DOI:10.1248/cpb.40.2055

NII-Electronic Library Service

Products guided by the article

Product name:2-Amino-5-o-tolyloxy-benzenethiol

Cas No:145744-93-0

R&D Labs maybe for 145744-93-0

Nanjing yieldpharma co.ltd

Contact:13813902930 025-52714267

Address:20 Fengji Road, Yuhua Economic Development Zone, Nanjing, Jiangsu, P. R. China
Zibo Jujin Chemical Industry Co., Ltd.（Dongming Jujin Chemical Industry Co., Ltd. ）

Contact:+86-533-2975022

Address:No.99 Shanquan Road, Zhangdian District
Yixing Zhenfen Medical Chemical Co.Ltd

Contact:86-510-87552708

Address:Fenshui ,Yixing city,Jiangsu
Shanghai Bocimed Pharmaceutical Co., Ltd.

website:http://www.bocimed.com

Contact:+86-21-68861632

Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
Shijiazhuang Haotian Chemical Co., Ltd.

Contact:86-311-85044374

Address:293 Donggang Road

Relevant to this article

Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter

Doi:10.1021/acs.jmedchem.0c01867
(2021)
Metal-free arylations via photochemical activation of the Ar-OSO ₂R bond in aryl nonaflates

Doi:10.1039/c3gc41009a
(2013)
Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids

Doi:10.1002/anie.202106654
(2021)
Chemical and enzyme-catalysed syntheses of enantiopure epoxide and diol derivatives of chromene, 2,2-dimethylchromene, and 7-methoxy-2,2-dimethylchromene (precocene-1)

Doi:10.1039/p19960001757
(1996)
Use of Intramolecular 1,5-Sulfur-Oxygen and 1,5-Sulfur-Halogen Interactions in the Design of N-Methyl-5-aryl- N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators

Doi:10.1021/acs.jmedchem.0c02173
(2021)
Sterically Hindered Organotin Compounds. Part 3. The Reaction Between Di-tert-butyltin Oxide and Organoboronic Acids

Doi:10.1039/DT9920003503
(1992)

Article Doi