Synthesis and antihypertensive activity of 3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1 ,5-benzothiazepin-4(5H)-one (diltiazem) derivatives having substituents at the 8 position

DOI: 10.1248/cpb.40.2055

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Chemical and Pharmaceutical Bulletin p. 2055 - 2061 (1992)

Update date:2022-07-29

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Authors:

Yanagisawa

Fujimoto

Shimoji Shimoji

Kanazaki

Mizutari

Nishino Nishino

Shiga Shiga

Koike Koike

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Article abstract of DOI:10.1248/cpb.40.2055

In order to improve the potency and duration of biological actions of diltiazem, a number of 1,5-benzothiazepine derivatives having the substituents at the 8 position were prepared and evaluated for their antihypertensive activity in spontaneously hyperte

Full text of DOI:10.1248/cpb.40.2055

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