Tetrahedron Letters p. 5343 - 5346 (1994)
Update date:2022-08-03
Topics:
Meinke, Peter T.
O'Connor, Stephen P.
Fisher, Michael H.
Mrozik, Helmut
The concise synthesis of avermectin analogs wherein the C23 carbon has been excised and replaced with an oxygen or sulfur atom is described.The new, heteroatom-substituted avermectins represent isosteres of 22,23-dihydro-avermectin B1a and, in the case of the sulfoxides and sulfones, are isosteric to avermectin B2a.These new avermectins bear diverse functionality at C24 and C25.
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