An Improved Synthesis of 5-Halopyrimidines: Reaction of α-Halo Ketones with Nitriles

DOI: 10.1055/s-1992-26296

Source and publish data:

Synthesis p. 1053 - 1054 (1992)

Update date:2022-08-03

Topics:

Authors:

Martinez, A. Garcia

Fernandez, A. Herrera

Vilchez, Dolores Molero

Hanack, M.

Subramanian, L. R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1992-26296

The reaction of alkyl and aryl α-halomethyl ketones 1 with aliphatic and aromatic nitriles 2 in the presence of trifluoromethanesulfonic anhydride affords substituted 5-halopyrimidines 3 in good yields (55-91percent).

Full text of DOI:10.1055/s-1992-26296

Products guided by the article

Product name:5-bromo-2,4,6-triphenylpyrimidine

Cas No:146070-73-7

R&D Labs maybe for 146070-73-7

GN chemicals co.,ltd

Contact:86 311 85902108 / 85902109

Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
SHANGHAI GILEADER ADVANCE MATERIAL TECHNOLOGY CO.,LTD

website:http://www.tanguitech.com/contact.asp

Contact:+86-021-58692556

Address:No.6 Building,No. 668 Hengan RD Pudong,Shanghai
Suzhou Credit International Trading Co., Ltd

Contact:+86-512-65398039

Address:Qingdeng, Hightech. District, Suzhou
SINO GREAT ENTERPRISE LTD.

Contact:+86-731-84427351

Address:154 JIANXIANG SOUTH ROAD
Xi'an Galaxy Chemicals CO., Ltd

Contact:86-29-89380370

Address:No.8, Gaoxin three road, Xi'an city.

Relevant to this article

A spacer-modified disaccharide as a photoaffinity reagent for the acceptor-binding area of bovine (1->4)-β-D-galactosyltransferase: comparison of its acceptor properties with those of other 2-acetamido-2-deoxy-β-D-glucopyranosides

Doi:10.1016/S0008-6215(00)90925-X
(1992)
A novel entry to the vitamin D triene system

Doi:10.1016/S0040-4039(00)60832-8
(1992)
A convenient N-protection of pyroglutamate derivatives

Doi:10.1080/00397919508011481
(1995)
Complexes of the Platinum Metals. Part 41. Oxidative-substitution Reactions at Ruthenium(II) and Osmium(II) involving N,N'-Diphenylamidinate Ligands

Doi:10.1039/DT9920003199
(1992)
A convenient synthetic approach to new α-(9-fluorenylmethoxycarbonylamino)alkylphosphonic acid derivatives

Doi:10.1055/s-1992-26344
(1992)
Profiling human Src homology 2 (SH2) domain proteins and ligand discovery using a peptide-hybrid small molecule microarray

Doi:10.1039/c3cc45413d
(2013)

Article Doi