An Improved Synthesis of 5-Halopyrimidines: Reaction of α-Halo Ketones with Nitriles

DOI: 10.1055/s-1992-26296

Source and publish data:

Synthesis p. 1053 - 1054 (1992)

Update date:2022-08-03

Topics:

Authors:

Martinez, A. Garcia

Fernandez, A. Herrera

Vilchez, Dolores Molero

Hanack, M.

Subramanian, L. R.

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Article abstract of DOI:10.1055/s-1992-26296

The reaction of alkyl and aryl α-halomethyl ketones 1 with aliphatic and aromatic nitriles 2 in the presence of trifluoromethanesulfonic anhydride affords substituted 5-halopyrimidines 3 in good yields (55-91percent).

Full text of DOI:10.1055/s-1992-26296

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