A Facile Synthesis of 2-exo-Methylenepenam; a Potent Intermediate for Syntheses of New β-Lactamase Inhibitors

DOI: 10.1039/c39920001793

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Journal of the Chemical Society. Chemical communications p. 1793 - 1794 (1992)

Update date:2022-09-26

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Authors:

Tanaka, Hideo

Kameyama, Yutaka

Yamauchi, Takahito

Torii, Sigeru

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Article abstract of DOI:10.1039/c39920001793

A convenient synthesis of 2-exo-methylenepenams 1 is performed by reductive cyclization of allenecarboxylates 8 in a BiCl3/Zn bimetal redox system; subsequent manipulation of the 2-exo-methylene moiety of 1 opens new entries to β-lactam antibiotics and/or

Full text of DOI:10.1039/c39920001793

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