Kinetic resolution of aliphatic 1,2-diols by a lipase-catalyzed sequential acetylation

Article abstract of DOI:10.1016/S0040-4039(00)60573-7

The kinetic resolution of 13 racemic aliphatic 1,2-diols (rac-1a-m) by means of a lipase-catalyzed sequential acetylation was investigated. The enantioselectivity of the 3-aryloxy-propane-1,2-diols rac-1a-k depends on the substitution pattern at the aryl ring.