Chemical and Pharmaceutical Bulletin p. 3253 - 3260 (1992)
Update date:2022-08-04
Topics:
Kawasaki
Hirase
Miyano
Tsuji
Iwamoto
N-Terminal tetrapeptide analogs of fibrin α-chain were synthesized by the solution method using a new active ester, the ester of the oxime of p-nitroacetophenone, and by the solid-phase method. Their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, amide analogs of Gly-Pro-Arg-Pro exhibited a more potent inhibitory effect.
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