Asymmetric dihydroxylation (AD) of N,N-dialkyl and N-methoxy-N-methyl α,β- and β,γ-unsaturated amides

Article abstract of DOI:10.1016/S0040-4039(00)60350-7

The asymmetric dihydroxylation of α,β- and β,γ-unsaturated amides affords the corresponding diols in good yields and excellent enantiomeric excesses. However, both N,N-dialkyl and N-methoxy-N-methyl α,β- and β,γ-unsaturated amides require a Modified-AD-mix formulation to achieve good catalytic turnover rates.