Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, - 1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents

DOI: 10.1021/jm00060a017

Source and publish data:

Journal of Medicinal Chemistry p. 1090 - 1099 (1993)

Update date:2022-08-05

Topics: 1,3,4-oxadiazole 1,2,4-triazole In vitro Testing In Vivo Testing Design Structure-Activity Relationship (SAR) Oral Bioavailability Antiinflammatory Agents Orally-Active 1,3,4-thiadiazole

Authors:

Mullican

Wilson Wilson

Connor Connor

Kostlan Kostlan

Schrier Schrier

Dyer Dyer

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00060a017

To discover dual inhibitors of 5-lipoxygenase (LO) and cyclooxygenase (CO) with improved pharmacokinetic properties, we have designed and synthesized series of 1,2,4-triazole, 1,3,4-oxadiazole, and 1,3,4-thiadiazole di-tert- butylphenol derivatives which

Full text of DOI:10.1021/jm00060a017

Products guided by the article

Product name:3,5-bis(1,1-dimethylethyl)-4-methoxybenzenecarboximidic acid hydrazide

Cas No:148773-27-7

R&D Labs maybe for 148773-27-7

Taiwan Surfactant Corp.

Contact:886 2 2541 0022

Address:8 Fl., No. 11, Sec. 1, Chung Shan North Rd., Taipei, Taiwan R.O.C.
Tianjin Chemsyntech Chemical Co., Ltd

Contact:+86-22-60872258

Address:Haitai green industry base in Tianjin, K1,5-601
SNC | GOOD FORTUNE

Contact:0086-22-2822 1962 / 2822 1963

Address:B-808, No. 1, North-South Street, Hexi District,
Antaeus Bio-technology Co., LTD(expird)

Contact:021-31252569

Address:shanghai pudong
Shanghai shibo Chemical Co., Ltd

Contact:+86-021-60753516

Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512

Relevant to this article

Iodine-catalyzed oxidative functionalization of purines with (thio)ethers or methylarenes for the synthesis of purin-8-one analogues

Doi:10.1039/d1ob00118c
(2021)
Preparative access to medicinal chemistry related chiral alcohols using carbonyl reductase technology

Doi:10.1016/j.tetasy.2013.09.015
(2013)
A concise and enantioselective synthesis of novel HIV-1 protease transition state mimics

Doi:10.1016/S0040-4039(00)91945-2
(1993)
Base mediated deprotection strategies for trifluoroethyl (TFE) ethers, a new alcohol protecting group

Doi:10.1016/j.tetlet.2013.10.097
(2013)
Synthesis and photophysical properties of two strongly fluorescent bis(diquinaldinatoalumino)-9-silafluorenes

Doi:10.1021/om4005803
(2013)
Synthetic Studies on Duocarmycin. 2. Synthesis and Cytotoxicity of Natural (+)-Duocarmycin A and Its Tree Possible Stereoisomers.

Doi:10.1016/S0040-4020(01)86994-5
(1994)

Article Doi