Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, - 1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents

DOI: 10.1021/jm00060a017

Source and publish data:

Journal of Medicinal Chemistry p. 1090 - 1099 (1993)

Update date:2022-08-05

Topics: 1,3,4-oxadiazole 1,2,4-triazole In vitro Testing In Vivo Testing Design Structure-Activity Relationship (SAR) Oral Bioavailability Antiinflammatory Agents Orally-Active 1,3,4-thiadiazole

Authors:

Mullican

Wilson Wilson

Connor Connor

Kostlan Kostlan

Schrier Schrier

Dyer Dyer

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Article abstract of DOI:10.1021/jm00060a017

To discover dual inhibitors of 5-lipoxygenase (LO) and cyclooxygenase (CO) with improved pharmacokinetic properties, we have designed and synthesized series of 1,2,4-triazole, 1,3,4-oxadiazole, and 1,3,4-thiadiazole di-tert- butylphenol derivatives which

Full text of DOI:10.1021/jm00060a017

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