A concise and enantioselective synthesis of novel HIV-1 protease transition state mimics

DOI: 10.1016/S0040-4039(00)91945-2

Source and publish data:

Tetrahedron Letters p. 1851 - 1854 (1993)

Update date:2022-08-05

Topics:

Authors:

Dorsey Dorsey

Plzak Plzak

Ball Ball

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Article abstract of DOI:10.1016/S0040-4039(00)91945-2

Novel HIV-1 protease inhibitors have been prepared in an enantioselective manner via an Evans asymmetric aldol, Claisen rearrangement and iodolactonization. X-ray crystallographic analysis was used to confirm the absolute configuration of the newly created stereogenic centers.

Full text of DOI:10.1016/S0040-4039(00)91945-2

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