A concise and enantioselective synthesis of novel HIV-1 protease transition state mimics

DOI: 10.1016/S0040-4039(00)91945-2

Source and publish data:

Tetrahedron Letters p. 1851 - 1854 (1993)

Update date:2022-08-05

Topics:

Authors:

Dorsey Dorsey

Plzak Plzak

Ball Ball

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)91945-2

Novel HIV-1 protease inhibitors have been prepared in an enantioselective manner via an Evans asymmetric aldol, Claisen rearrangement and iodolactonization. X-ray crystallographic analysis was used to confirm the absolute configuration of the newly created stereogenic centers.

Full text of DOI:10.1016/S0040-4039(00)91945-2

Products guided by the article

Product name:(E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester

Cas No:149228-51-3

R&D Labs maybe for 149228-51-3

Zhejiang Hoshine Silicon Industry Co., Ltd.

Contact:86-573-89179966

Address:Zhapu Town, Pinghu City, Zhejiang, China
Suzhou CarbonWell Pharma-Tech Co., Ltd

Contact:Tel: + 86 (0)512-8898-1216; + 86-18606258602

Address:2358 Changan Road, Wujiang Scientific Innovation Park, Wujiang, Jiangsu Province, P. R. China 215200
Tangshan Wisdom Trading Co.,Ltd

Contact:86 315 2222979

Address:No.41 BeiXinXi Road, Yangguang building 1-1102 , Tangshan, Hebei, China
QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.

Contact:+86 532 80861829

Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Henan Harvest Chem Co., Ltd

Contact:+86-371-86058576

Address:NO.32, Jingsan Road, Zhengzhou, China

Relevant to this article

Doi:10.1021/ja01156a115
(1951)
Dramatically improved catalytic activity of an artificial (S)-selective arylmalonate decarboxylase by structure-guided directed evolution

Doi:10.1039/c1cc11953b
(2011)
Monometallic nickel(II) complexes containing N,N′-iminopyridine chelating ligands with dendritic substituents: The influence of dendrimer topology on the catalytic oligomerization and polymerization of ethylene Metallodendrimers Special Issue

Doi:10.1016/j.ica.2013.07.025
(2014)
Synthesis and properties of pentafluorosulfanyl group (Sf₅)-containing meta-diamide insecticides

Doi:10.3390/molecules25235536
(2020)
A novel synthesis of compounds containing, a fused pyrrole ring from cyclic ketones and N-BOC-L-phenylalaninal

Doi:10.1016/S0040-4039(00)60900-0
(1992)
Anisotropic glass freezing in rubidium/ammonium dihydrogen phosphate mixed crystal and its deuterated analogue

Doi:10.1088/0953-8984/9/21/007
(1997)

Article Doi