Chemical and Pharmaceutical Bulletin p. 445 - 452 (1993)
Update date:2022-09-26
Topics:
Kato
Fujita
Fujimura
Kawashima
Nishiyama
Citrusinine-I (1), a naturally occurring acridone alkaloid with potent antiviral activity, was synthesized for the first time, via a route involving Ullmann reaction, cyclization, and selective demethylation at the 1-position with boron trifluoride etherate and lithium bromide. 1,5,6-Trihydroxy-3-methoxy-9(10H)-acridone (2a) and 1,5,6-trihydroxy-3-methoxy-10-methyl-9(10H)-acridone (2b) were also synthesized.
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Doi:10.1002/jlcr.2580340312
(1994)Doi:10.1016/j.tet.2013.01.076
(2013)Doi:10.1016/j.lfs.2007.11.016
(2008)Doi:10.1071/CH9671049
(1967)Doi:10.1021/jo00292a006
(1990)Doi:10.1039/J19660001670
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