Effect of Trifluoromethyl and Other Substituents on Activity of Xanthines at Adenosine Receptors

DOI: 10.1021/jm00070a007

Source and publish data:

Journal of Medicinal Chemistry p. 2639 - 2644 (1993)

Update date:2022-08-02

Topics: Xanthines Structure-Activity Relationship (SAR) Synthetic Chemistry Dose-Response Curve Hydrophobicity Substituent Electron-withdrawing group Radioligand Binding Assay Ki (Inhibition constant) IC??

Authors:

Jacobson, Kenneth A.

Shi, Dan

Gallo-Rodriguez, Carola

Manning, Malcolm

Mueller, Christa

et al. et al.

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Article abstract of DOI:10.1021/jm00070a007

An aryl p-(trifluoromethyl) substituent increases the affinity of 1,3-disubstituted 8-phenylxanthines at A_2a-adenosine receptors, while having little effect on affinity at A₁-adenosine receptors.In contrast, an aryl p-(trifluoromethy

Full text of DOI:10.1021/jm00070a007

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