Journal of Medicinal Chemistry p. 2639 - 2644 (1993)
Update date:2022-08-02
Topics: Xanthines Structure-Activity Relationship (SAR) Synthetic Chemistry Dose-Response Curve Hydrophobicity Substituent Electron-withdrawing group Radioligand Binding Assay Ki (Inhibition constant) IC??
Jacobson, Kenneth A.
Shi, Dan
Gallo-Rodriguez, Carola
Manning, Malcolm
Mueller, Christa
et al.
An aryl p-(trifluoromethyl) substituent increases the affinity of 1,3-disubstituted 8-phenylxanthines at A2a-adenosine receptors, while having little effect on affinity at A1-adenosine receptors.In contrast, an aryl p-(trifluoromethy
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Doi:10.1021/jo00070a001
(1993)Doi:10.1007/s10973-005-7209-3
(2006)Doi:10.1080/00397919308011209
(1993)Doi:10.1016/S0040-4020(01)85754-9
(1993)Doi:10.1021/ol7016577
(2007)Doi:10.1021/ol0483854
(2004)
