Journal of Organic Chemistry p. 3850 - 3856 (1993)
Update date:2022-08-05
Topics:
Denmark, Scott E.
Marcin, Lawrence R.
A general and expeditious route for the preparation of functionalized 2,2-disubstituted 1-nitroalkenes has been developed.Conjugate 1,4-addition of complex zinc cuprates (RCu(CN)ZnI) to easily obtained (E)-1-nitroalkenes, followed by trapping with phenylselenenyl bromide and subsequent oxidative elimination, afforded the corresponding 2,2-disubstituted 1-nitroalkenes in good yields. 2-Alkyl-2-aryl- and 2,2-dialkyl nitroalkenes 4b-g were prepared in 76-88percent yield and obtained as E/Z isomeric mixtures, slightly favoring the Z isomer (ca. 1.0:1.5, E/Z).
View MoreDongying J&M Chemical Co., Ltd,
Contact:546-8551108
Address:Room 1219, Zisheng Mansion, Zibo Road, Dongying, Shandong, China
Contact:+86 512 6287 2180
Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
Jintan Jinnuo Chemical Co., Ltd.
Contact:+86-519-80199901
Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
website:http://www.shtopchem.com/
Contact:0086-0576-87776998
Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Contact:86-25-84683399
Address:605, Phoenix Herui Plaza, No.389, South Taiping Road, Nanjing, China 210002
Doi:10.1021/ol403041k
(2014)Doi:10.1039/c39940000035
(1994)Doi:10.1021/jm00072a009
(1993)Doi:10.1135/cccc19930941
(1993)Doi:10.1134/S0022476613040161
(2013)Doi:10.1021/ja00077a055
(1993)
