Facile access to 2′-O-acyl prodrugs of 1- (β-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2′ 3′, 5′-triesters

DOI: 10.1016/S0040-4039(00)93411-7

Source and publish data:

Tetrahedron Letters p. 3177 - 3180 (1993)

Update date:2022-08-04

Topics:

Authors:

Baraldi, Pier G.

Bazzanini, Rita

Manfredini, Stefano

Simoni, Daniele

Robins, Morris J.

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Article abstract of DOI:10.1016/S0040-4039(00)93411-7

Treatment of 1-(2,3,5-tri-O-acetyl-β-_D-arabinofuranosyl) -5-[2-(trimethylsilyl)-vinyl]uracil (3) with pyridinium bromide perbromide and deacetylation gave BVAraU (2). Pig liver esterase (EC 3.1.1.1) catalysed the regioselective hydrolysis of 1-

Full text of DOI:10.1016/S0040-4039(00)93411-7

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