Synthesis of new 5-substituted 1,2,4-triazole-3-thione derivatives

Article abstract of DOI:10.1080/10426500008045234

In the present paper we describe the preparation of series of new derivatives of 1,2,4-triazole-3-thiol. As starting materials methyl 3-acyldithiocarbazates were used, which on reaction with amines gave the corresponding 4,5-disubstituted 1,2,4-triazole-3-thiol derivatives (3). Into the 4-position of the 1,2,4-triazole-3-thiol system a β-hydroxyetlhyl substituent was introduced (compounds 4). These compounds were alkylated with methyl iodide to from 6, with N-substituted amides of chloroacetic acid (products 7 and 8), and aminomethylated with formation of Mannich bases (10). Some of the thiols 4 were desulfurized to 9. The new compounds were tested for their circulatory activity, but found not pharmacologically active.

Full text of DOI:10.1080/10426500008045234

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Phosphorus, Sulfur, and Silicon
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SYNTHESIS OF NEW 5-
SUBSTITUTED 1,2,4-
TRIAZOLE-3-THIONE
DERIVATIVES
Henryk Foks a c , Anna Czarnocka-janowicz a
Waleria Rudnicka a & Henryk Trzeciak b
,
a Department of Organic Chemistry, Medical
University of GdańSk, Poland
b Department of Pharmacology, Silesian Medical
University of Katowice, Poland
c Al. Gen. J. Hallera 107, 80416, Gdańsk, Poland
Version of record first published: 27 Oct 2006.
To cite this article: Henryk Foks , Anna Czarnocka-janowicz , Waleria Rudnicka &
Henryk Trzeciak (2000): SYNTHESIS OF NEW 5-SUBSTITUTED 1,2,4-TRIAZOLE-3-THIONE
DERIVATIVES, Phosphorus, Sulfur, and Silicon and the Related Elements, 164:1, 67-81
To link to this article: http://dx.doi.org/10.1080/10426500008045234
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