Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazephines as cholecystokinin-B receptor antagonists

DOI: 10.1021/jm990967h

Source and publish data:

Journal of Medicinal Chemistry p. 3596 - 3613 (2000)

Update date:2022-09-26

Topics:

Authors:

Ursini Ursini

Capelli Capelli

Carr Carr

Cassarà

Corsi Corsi

Curcuruto

Curotto Curotto

Dal Cin Dal Cin

Davalli Davalli

Donati Donati

Feriani Feriani

Finch Finch

Finizia Finizia

Gaviraghi

Marien Marien

Pentassuglia

Polinelli

Ratti Ratti

Reggiani

Tarzia Tarzia

Tedesco Tedesco

Tranquillini

Trist Trist

Van Amsterdam

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Article abstract of DOI:10.1021/jm990967h

A series of 5-phenyl-3-ureidobenzodiazepine-2,4-diones was synthesized and evaluated as cholecystokinin-B (CCK-B) receptor antagonists. Structure-activity relationship (SAR) studies revealed the importance of the N-1 substituent for potent and selective C

Full text of DOI:10.1021/jm990967h

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