Synthesis of 1-O-Acylglycerol 2,3-Cyclic Phosphate: Determination of the Absolute Structure of PHYLPA, A Specific Inhibitor of DNA Polymerase α

Article abstract of DOI:10.1016/S0040-4039(00)60612-3

Four possible stereoisomers of PHYLPA, a specific inhibitor of DNA polymerase α, were synthesized in enantioselective manners.These isomers were examined for inhibition activity for DNA polymerase α, and the structure of PHYLPA was established as sodium 1-O-<(9'S,10'R)-9',10'-methanohexadecanoyl>-sn-glycerol 2,3-cyclic phosphate.