Archiv der Pharmazie p. 273 - 278 (1996)
Update date:2022-09-26
Topics:
Capraro, Hans-Georg
Bold, Guido
Faessler, Alexander
Cozens, Robert
Klimkait, Thomas
Lazdins, Janis
Mestan, Juergen
Poncioni, Bernard
Roesel, Johannes L.
Stover, David
Lang, Marc
A series of potent HIV-protease inhibitors has been prepared. Several of the newly synthesized compounds showed high plasma levels after oral administration to animals. Based on the overall biological profile, CGP 61755 was chosen for further preclinical evaluation. For this compound, a 10 step synthesis potentially suitable for large scale production was developed.
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Doi:10.1016/S0277-5387(00)86505-5
(1989)Doi:10.1002/adfm.201202132
(2013)Doi:10.1002/ejoc.201600784
(2016)Doi:10.1021/jacs.5b02775
(2015)Doi:10.1002/adsc.201200695
(2013)Doi:10.1021/acs.joc.9b02073
(2019)
