Archiv der Pharmazie p. 273 - 278 (1996)
Update date:2022-09-26
Topics:
Capraro, Hans-Georg
Bold, Guido
Faessler, Alexander
Cozens, Robert
Klimkait, Thomas
Lazdins, Janis
Mestan, Juergen
Poncioni, Bernard
Roesel, Johannes L.
Stover, David
Lang, Marc
A series of potent HIV-protease inhibitors has been prepared. Several of the newly synthesized compounds showed high plasma levels after oral administration to animals. Based on the overall biological profile, CGP 61755 was chosen for further preclinical evaluation. For this compound, a 10 step synthesis potentially suitable for large scale production was developed.
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Changsha Yihai Chemical Technology Co.,ltd
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HANGZHOU TOYOND BIOTECH CO., LTD
Contact:+86-571-86965177
Address:No. 189, Fengqi East Road, Hangzhou, China
Shanggao Ruiya Fine Chemicals Co., Ltd
Contact:+86-795-2592103
Address:Xingguang Nanlu,Shanggao County Industry Park
Doi:10.1016/S0277-5387(00)86505-5
(1989)Doi:10.1002/adfm.201202132
(2013)Doi:10.1002/ejoc.201600784
(2016)Doi:10.1021/jacs.5b02775
(2015)Doi:10.1002/adsc.201200695
(2013)Doi:10.1021/acs.joc.9b02073
(2019)
