Synthesis of (-)-bullatacin: The enantiomer of a potent, antitumor, 4-hydroxylated, Annonaceous acetogenin

Article abstract of DOI:10.1016/S0040-4039(00)60671-8

Synthesis of the title compound represents the first construction of any of these potent, antitumor Annonaceous acetogenins with the entire relative stereochemistry in place. Palladium(0)-mediated crossed diyne coupling and the use of three, natural, α-hy