Radioprotective effect of low doses of 2-(1-naphthylmethyl)-2-imidazoline alone or associated with phosphorothioates

Article abstract of DOI:10.1016/0223-5234(93)90030-I

In the mouse, the intraperitoneal injection of 2-(1-naphthylmethyl)-2-imidazoline has a radioprotective effect even at low doses.Its association with S-<2-(3-aminopropyl)aminoethyl> phosphorothioate (WR 2721) or S-<3-(3-methylaminopropyl)-aminopropyl>phosphorothioate (WR 151327) at low doses led to an ethancement of their respective radioprotective activities without any apparent side effects.These results strengthen the interest of this non-sulphur compound as a radioprotector. radioprotective compounds/phosphorothioates/WR 2721/WR 151327/imidazoline/associations