Journal of Organic Chemistry p. 7382 - 7387 (1993)
Update date:2022-08-03
Topics:
Huang, Chialang G.
Rozov, Leonid A.
Halpern, Donald F.
Vernice, Gerald G.
The enantiomers of the inhalation anesthetic agent, isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether), are prepared by a synthesis starting from 2,2,2-trifluoroethanol. (R)-(+)-Dehydroabietylamine is used as the resolving agent for the racemic acid intermediate 1.The optical purities of both (S)-(+)- and (R)-(-)-isofluranes are determined to be >99percent ee (enantiomeric excess) by chiral capillary gas chromatography.
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Doi:10.1021/jm00315a061
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