Convergent synthesis of a key intermediate for hypocholesterolemic agent 1233A, starting from methyl 3-hydroxy-2-methylpropanoate and asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA*)

DOI: 10.1016/S0040-4039(00)73162-5

Source and publish data:

Tetrahedron Letters p. 4239 - 4242 (1994)

Update date:2022-08-05

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Authors:

Guanti, Giuseppe

Banfi, Luca

Schmid, Giovanna

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Article abstract of DOI:10.1016/S0040-4039(00)73162-5

Compound 2, which is a known intermediate for the total synthesis of hypocholesterolemic agent 1233A 1, has been synthesized in good overall yield through a convergent approach, employing 3-hydroxy-2-methylpropanoate 6 and BHYMA* 5 as chiral building bloc

Full text of DOI:10.1016/S0040-4039(00)73162-5

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Product name:(R)-3-<<(t-butyldimethyl)silyl>oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-1-propanol

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