Bioorganic and Medicinal Chemistry Letters p. 323 - 328 (1996)
Update date:2022-07-30
Topics:
Caldwell
Sahoo
Polo
Eversole
Lanza
Mills
Niedzwiecki
Izquierdo-Martin
Chang
Harrison
Kuo
Lin
Stein
Durette
Hagmann
The matrix metalloproteinase stromelyin-1 (MMP-3) is inhibited more strongly by peptidyl phosphinic acid 7 than by its corresponding phosphonamidate and phosphonate analogs. Extending a benzyl group at P1' to a phenylethyl group in 8 further increases the potency (K(i) = 1.4 nM). Enhanced potency with an extended substituent into the P3 region was observed.
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