Bioorganic and Medicinal Chemistry Letters p. 323 - 328 (1996)
Update date:2022-07-30
Topics:
Caldwell
Sahoo
Polo
Eversole
Lanza
Mills
Niedzwiecki
Izquierdo-Martin
Chang
Harrison
Kuo
Lin
Stein
Durette
Hagmann
The matrix metalloproteinase stromelyin-1 (MMP-3) is inhibited more strongly by peptidyl phosphinic acid 7 than by its corresponding phosphonamidate and phosphonate analogs. Extending a benzyl group at P1' to a phenylethyl group in 8 further increases the potency (K(i) = 1.4 nM). Enhanced potency with an extended substituent into the P3 region was observed.
View MoreQINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.
Contact:+86 532 80861829
Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
HANGZHOU FOREWIN PHARMA CO., LTD
Contact:+86-571-89053961
Address:hangzhou
Anhui New Star Pharmaceutical Development Co., Ltd
Contact:013956922763
Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
Contact:+86-710-3516804
Address:Number 83,Panggong road,Xiangcheng District,Xiangyang ,Hubei
Contact:+86-515-88356562
Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
Doi:10.1021/jm00028a013
(1994)Doi:10.1016/j.tetlet.2016.06.044
(2016)Doi:10.1021/jo402511b
(2014)Doi:10.1016/0022-328X(93)83139-M
(1993)Doi:10.1002/chem.201303115
(2013)Doi:10.1021/ja412194w
(2014)
