Phosphinic acid inhibitors of matrix metalloproteinases

DOI: 10.1016/0960-894X(96)00023-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 323 - 328 (1996)

Update date:2022-07-30

Topics:

Authors:

Caldwell

Sahoo Sahoo

Polo Polo

Eversole

Lanza Lanza

Mills Mills

Niedzwiecki

Izquierdo-Martin

Chang Chang

Harrison

Kuo Kuo

Lin Lin

Stein Stein

Durette Durette

Hagmann Hagmann

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00023-6

The matrix metalloproteinase stromelyin-1 (MMP-3) is inhibited more strongly by peptidyl phosphinic acid 7 than by its corresponding phosphonamidate and phosphonate analogs. Extending a benzyl group at P₁' to a phenylethyl group in 8 further increases the potency (K(i) = 1.4 nM). Enhanced potency with an extended substituent into the P₃ region was observed.

Full text of DOI:10.1016/0960-894X(96)00023-6

Products guided by the article

Product name:benzyl 2-((hydroxy(methyl)phosphinyl)methyl)-4-phenylbutanoate

Cas No:153642-89-8

R&D Labs maybe for 153642-89-8

Taizhou Sunny Chemical Co.,Ltd

Contact:+86-523-86920899 +86-13951172783

Address:No.11 Xingyuang road, Gaoyong Chemical Industry Park, Gaogang Jiangsu China
Jiangxi Dongxu Chemical Science & Technology Co.,Ltd

Contact:+86-791-86899381

Address:Nanchang, Jiangxi, China
Xi'an Kaixiang Photoelectric Technology Co., Ltd

website:http://www.kxmaterials.com/

Contact:86-29-15991651477

Address:Building 6, Biopharmaceutical Industry R&D Cluster Base, No. 16, Caotang 4th Road, Caotang Science and Technology Industrial Base, High-tech Zone, Xi'an City, Shaanxi Province, China
Chengdu Gelipu Biotechnology Co., Ltd.

website:http://www.glp-china.com

Contact:86-28-82610909

Address:chegndu
enantiotech corporation ltd

Contact:+86-0760-85282375

Address:zhongjing road,zhongshan torch hi-tech industrial development zone

Relevant to this article

Evaluation of a Vitamin-Cloaking Strategy for Oligopeptide Therapeutics: Biotinylated HIV-1 Protease Inhibitors

Doi:10.1021/jm00028a013
(1994)
Copper-catalyzed C–N cross-coupling of arylboronic acids with N-acylpyrazoles

Doi:10.1016/j.tetlet.2016.06.044
(2016)
Catalytic C6 functionalization of 2,3-disubstituted indoles by scandium triflate

Doi:10.1021/jo402511b
(2014)
ortho-Directed electrophilic boronation of a benzyl ketone: the preparation, X-ray crystal structure, and some reactions of 4-ethyl-1-hydroxy-3-(4-hydroxyphenyl)-2-oxa-1-boranaphthalene

Doi:10.1016/0022-328X(93)83139-M
(1993)
Synthesis and bonding in carbene complexes of an unsymmetrical dilithio methandiide: A combined experimental and theoretical study

Doi:10.1002/chem.201303115
(2013)
In vitro characterization of LmbK and LmbO: Identification of GDP-d-erythro-α-d-gluco-octose as a key intermediate in lincomycin a biosynthesis

Doi:10.1021/ja412194w
(2014)

Article Doi