Journal of Antibiotics p. 1740 - 1751 (1993)
Update date:2022-09-26
Topics:
Nishi
Higashi
Takemura
Sato
A new type of penem derivative (3 ~ 6) having a cyclic amidine moiety or a quaternary heterocycle moiety at the C-2 position was prepared. The susceptibility to renal dehydropeptidase-1 (DHP-1) and the antimicrobial activity of these compounds were determined. Some of these compounds (5,6) showed a broad spectrum of antibacterial activity, including activity against Pseudomonas aeruginosa.
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