Chemistry and Physics of Lipids p. 161 - 170 (1993)
Update date:2022-08-02
Topics:
Duclos, Richard I.
A general method for the chirospecific synthesis of 1-acyl-2-alkyl-sn-glycero-3-phosphocholines is described. 1-Palmityl-2-hexadecyl-sn-glycero-3-phosphocholine (PHPC) was synthesized in 18percent overall yield in ten steps via five new synthetic intermediates, and 1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine (AHPC) was also synthesized. 1-Acetyl-2-alkyl-sn-glycero-3-phosphocholines, which have not been found to exist in nature, are ether lipid analogs of 1,2-diacetyl-sn-glycero-3-phosphocholines, which are important components of cell membranes.Biophysical studies of hydrated bilayers of PHPC will be of interest in probing the critical importance of the central region of these amphiphilic molecules to the molecular assemblies that are found. Key words: 1-Acetyl-2-alkyl-sn-glycero-3-phosphocholine; 1-Palmitoyl-2-hexadecyl-sn-glycero-3-phosphocholine; PHPC; 1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine; AHPC; Palmitic anhydride
View MoreWuxi Innopal International Trade CO.,LTD
Contact:+86-510-80711901-8003
Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Quhua Zhongxing Refrigeration Technology Co.,Ltd.
Contact:+86-5708886618
Address:318 Bulding 2, No.866 Quhua Rd.,Kecheng District
Cangzhou Senary Chemical Science-tech Co., Ltd
Contact:+86-317-3563899, 3563699
Address:168 Jinde Road, Cangzhou, Hebei, China
FREEBARQUE DEVELOPMENT GROUP LIMITED
Contact:+86(0)10-5109 5335 or 5109 5345
Address:Room602,Block1-B,LINGDI OFFICE,NO.13 BEIYUAN ROAD
Shanghai Forever Synthesis Co.,Ltd.
Contact:021-61124658
Address:Zhoukang Road,Pudong New District,Shanghai,China
Doi:10.1016/j.jsbmb.2014.01.013
(2014)Doi:10.1021/jm00013a022
(1995)Doi:10.1016/S0040-4039(02)01539-3
(2002)Doi:10.1016/j.jorganchem.2017.12.002
(2018)Doi:10.1021/acs.joc.9b02810
(2020)Doi:10.1021/acs.joc.9b00557
(2019)