Efficient synthesis of 2,3,4,5-tetrahydro-1H-3-benzazepines by intramolecular Heck reaction

DOI: 10.1055/s-1993-25961

Source and publish data:

Synthesis p. 876 - 880 (1993)

Update date:2022-07-29

Topics:

Authors:

Tietze Tietze

Schimpf Schimpf

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Article abstract of DOI:10.1055/s-1993-25961

A new facile method for the synthesis of the pharmacologically interesting 3-benzazepine skeleton is described. The easily available iodinated benzene derivative 3 is alkylated with allyl halides 4a-c to afford compounds 5a-c. Pd-catalyzed Heck-type cycli

Full text of DOI:10.1055/s-1993-25961

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