Chiral 2-cyano esters as synthetic intermediates in the synthesis of R and S-α-methylvaline

DOI: 10.1016/0040-4020(95)00260-F

Source and publish data:

Tetrahedron p. 5921 - 5928 (1995)

Update date:2022-09-26

Topics: NMR spectroscopy Chiral Enantiomeric excess (ee) Recrystallization Hydrolysis Mass spectrometry (MS) Enantioselective synthesis Nucleophilic addition Optical rotation Deprotection Asymmetric catalysis Resolution Diastereomers Chiral Auxiliary Synthetic intermediates

Authors:

Cativiela

Diez-De-Villegas

Galvez Galvez

Lapena Lapena

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Article abstract of DOI:10.1016/0040-4020(95)00260-F

A divergent stereoselective synthesis of R and S α-methylvaline from (2RS) (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3-methylbutanoate has been developed.

Full text of DOI:10.1016/0040-4020(95)00260-F

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Product name:(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2,3-dimethylbutanoate

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