Short-step asymmetric syntheses of anthracycline antibiotics via enantioselective dihydroxylation by osmium tetroxide with a chiral diamine

Article abstract of DOI:10.1016/S0040-4020(01)80235-0

Short-step asymmetric syntheses of (+)-7-dehydroxy-4-demethoxydaunomycinone 4 and (-)-9-deacetyl-7-dehydroxy-4-demethoxy-9-hydroxymethyldaunomycinone 5 were accomplished via enantioselective dihydroxylation by osmium tetroxide with chiral diamine 13.