Bulletin of the Chemical Society of Japan p. 3551 - 3561 (1996)
Update date:2022-09-26
Topics:
Murata, Takeshi
Kumagai, Toshihito
Ishikawa, Makoto
Tadano, Kin-Ichi
Ogawa, Seiichiro
The thermal intramolecular Diels-Alder cycloaddition of a 2:1 mixture of ethyl (2E,8E and Z,10E,13R)-13-(t-butyldimethylsilyl) oxy-2,10-dimethyl-2,8,10-pentadecatrienoate provided four diastereomeric cycloadducts. Deprotection of one of the cycloadducts provided PI-201, a novel platelet aggregation inhibitor, as its natural form. Three stereoisomers of PI-201 were prepared from the other cycloadducts. The intramolecular cycloadditions of some structurally similar trienes were also investigated.
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