Tetrahedron p. 941 - 956 (1994)
Update date:2022-08-03
Topics:
Pyne
Safaei
Hockless
Skelton
Sobolev
White
The thermally induced Diels-Alder reactions of (R)-2-phenyl-4-methylene-oxazolidin-5-one 2 and substituted 1,3-cyclohexadienes and substituted 1,3-butadienes gives exo diastereomeric Diels-Alder adducts. In some cases the initially formed adducts undergo epimerization at the amino-acetal carbon, however the stereochemical integrity of the quaternary α-amino acid stereogenic centre is maintained and Diels-Alder adducts can be obtained in high enantiomeric purity (>90% ee). The stereochemistry of these adducts has been elucidated by single crystal X-ray structure determinations and 2D 1H NMR analysis.
View MoreSHANGHAI RC CHEMICALS CO.,LTD.
website:http://www.rcc.net.cn
Contact:+86-21-50322175
Address:Rm1415 Yinqiao Masion No.58 Jinxin Road Pudong Shanghai China
Guangxi Shanyun Biochemical Science and Technology Co., Ltd
Contact:+86-0772--6828887
Address:#2 Industrial Park of Luzhai County, Liuzhou, Guangxi, China
Anhui Biochem United Pharmaceutical Co., Ltd.
Contact:0086 551 5167062 / 5228268
Address:No. 30 Hongfeng Road, Hi-Tech Development Zone, Hefei (230088), China
Contact:0792-8228321
Address:10TH Floor No.121 binjiang Road Xunyang District
Shanghai Mio Chemical Co., Ltd
Contact:0086 21- 64401188-622
Address:16 Floor NO.2 Jiefang Building, No. 4855 Dushi Road, 201100 Shanghai, P.R.China
Doi:10.1002/jhet.5570350127
(1998)Doi:10.1016/0022-328X(94)88009-3
(1994)Doi:10.1016/j.ejmech.2013.10.072
(2014)Doi:10.1002/hlca.19940770105
(1994)Doi:10.1002/cctc.201403048
(2015)Doi:10.1021/ol0490633
(2004)