Total synthesis of halichondrin B from common sugars: An F-ring intermediate from D-glucose and efficient construction of the C1 to C21 segment

Article abstract of DOI:10.1016/S0040-4039(00)61388-6

An F-ring intermediate 7, with correct absolute configurations for the stereocenters at positions 17 and 20 of halichondrin B, is readily available from D-glucose. The practical utility of methoxybenzyl furanoside derivatives was demonstrated during incorporation of 7 into an acid-sensitive C1 to C21 segment.