Tetrahedron Letters p. 849 - 852 (1996)
Update date:2022-07-30
Topics:
Micouin
Quirion
Husson
Optically pure 2,3-cis-disubstituted piperidines 7a and 7b have been prepared from chiral lactams 2. The first step involves C-2 functionalization with Grignard reagent, then a diastereoselective reduction of resulting oxazolidines 5 furnishes the desired
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