Asymmetric synthesis. XL. 2,3-Disubstituted piperidines via chiral non-racemic lactams

DOI: 10.1016/0040-4039(95)02307-0

Source and publish data:

Tetrahedron Letters p. 849 - 852 (1996)

Update date:2022-07-30

Topics:

Authors:

Micouin Micouin

Quirion Quirion

Husson Husson

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Article abstract of DOI:10.1016/0040-4039(95)02307-0

Optically pure 2,3-cis-disubstituted piperidines 7a and 7b have been prepared from chiral lactams 2. The first step involves C-2 functionalization with Grignard reagent, then a diastereoselective reduction of resulting oxazolidines 5 furnishes the desired

Full text of DOI:10.1016/0040-4039(95)02307-0

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