Synthesis and testing of heterocyclic analogues of diaminopimelic acid (DAP) as inhibitors of DAP dehydrogenase and DAP epimerase

DOI: 10.1021/ja00094a004

Source and publish data:

Journal of the American Chemical Society p. 6513 - 6520 (1994)

Update date:2022-07-31

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Authors:

Abbott, Shaun D.

Lane-Bell, Patricia

Sidhu, Kanwar P. S.

Vederas, John C.

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Article abstract of DOI:10.1021/ja00094a004

Substrate analogues were synthesized and examined as inhibitors of diaminopimelic acid (DAP) dehydrogenase from Bacillus sphaericus and of DAP epimerase from Escherichia coli. These enzymes produce meso-DAP (3) (a precursor for L-lysine and for peptidogly

Full text of DOI:10.1021/ja00094a004

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