Synthesis of (2R)- and (2S)-β-D-glucopyranos-1-yl-2-O-palmitoyl-3-O-phosphatidylcholinylglyc erol: A new antifungal phosphocholine

Article abstract of DOI:10.1021/jo00128a043

The discovery of a new of antifungal agent, a glycosylated phosphatidylcholine, is reported, and the syntheses of the first two members of this series, (2S)-β-D-glucopyranos-1-yl-2-O-palmitoyl-3-O-phosphatidylcholinylglyc erol and (2R)-β-D-glucopyranos-1-yl-2-O-palmitoyl-3-O-phosphatidylcholinylglyc erol, are described. Their activities against the pathogenic fungi Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus are also reported.