Monatshefte fur Chemie p. 565 - 570 (1994)
Update date:2022-08-03
Topics:
Rybar, A.
Alfoeldi, J.
Smondrkova, I.
The synthesis of 8-allyltheophylline (8) from 5,6-diamino-1,3-dimethyluracil (1) and 3-butenoic acid by Traube's method via 6-amino-5-(3-butenoylamino)-1,3-dimethyluracil (2) failed because an attempted alkaline cyclization of the intermediate 2 afforded (E)-8-(1-propenyl)-theophylline (3) under rearrangement of the terminal C=C bond.Therefore, the cyclodehydratation of 6-(3-butenylamino)-5-nitroso-1,3-dimethyluracil (7), available from 6-chloro-1,3-dimethyluracil (5) via 6-(3-butenylamino) derivative 6 has to be used for obtaining the required product 8. - Keywords: 8-Allyltheophylline; 8-(1-Propenyl)-theophylline; Rearrangement of the terminal C=C bond.
View MoreGeen Chemical Technology Co., Ltd
Contact:86-769-21660847
Address:1408, Yingfeng Commercial Center, Nancheng District
Taizhou Crene Biotechnology co.ltd
Contact:86-576-88813233 88205808
Address:Economic Developed Zone of Taizhou Zhejiang China
WUXI HONOR SHINE CHEMICAL CO.,LTD
Contact:+86-510-83593312
Address:No.1699 Huishan avenue,Huishan district,Wuxi ,Jiangsu,China,214177.(Wuxi Huishan Ecomonic Develop Zone )
website:http://www.easchem.com
Contact:+86-731-89722861 89722891
Address:2/F-4/Bld Colorful Palace, No.605 Changsha Ave, Yuhua Area Changsha Hunan China.
website:http://www.maisonchem.com.cn
Contact:0086-311-83833777
Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
Doi:10.1021/om401104g
(2014)Doi:10.1021/acs.joc.8b02389
(2019)Doi:10.1134/S1070363207120031
(2007)Doi:10.1016/S0040-4039(00)77041-9
(1994)Doi:10.1007/BF00901415
(1967)Doi:10.1016/j.ica.2013.12.027
(2014)
