Monatshefte fur Chemie p. 565 - 570 (1994)
Update date:2022-08-03
Topics:
Rybar, A.
Alfoeldi, J.
Smondrkova, I.
The synthesis of 8-allyltheophylline (8) from 5,6-diamino-1,3-dimethyluracil (1) and 3-butenoic acid by Traube's method via 6-amino-5-(3-butenoylamino)-1,3-dimethyluracil (2) failed because an attempted alkaline cyclization of the intermediate 2 afforded (E)-8-(1-propenyl)-theophylline (3) under rearrangement of the terminal C=C bond.Therefore, the cyclodehydratation of 6-(3-butenylamino)-5-nitroso-1,3-dimethyluracil (7), available from 6-chloro-1,3-dimethyluracil (5) via 6-(3-butenylamino) derivative 6 has to be used for obtaining the required product 8. - Keywords: 8-Allyltheophylline; 8-(1-Propenyl)-theophylline; Rearrangement of the terminal C=C bond.
View MoreKaiping Genuine Biochemical Pharmaceutical Co.,Ltd.
Contact:+86-750-2881198
Address:No.1, Xinke Road, Shatang Town, Kaiping, Guangdong Province, P.R.China
Nanjing Fayekong Chemcial Co.,Ltd(expird)
Contact:86-25-58813444
Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
Wuhan Hanye Chemical New Material Co.,Ltd
Contact:+86-27-85308141
Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
Tangshan Wisdom Trading Co.,Ltd
Contact:86 315 2222979
Address:No.41 BeiXinXi Road, Yangguang building 1-1102 , Tangshan, Hebei, China
Contact:0086-27-83607103/83642615
Address:No.498, Jianshe Ave, Wuhan, China
Doi:10.1021/om401104g
(2014)Doi:10.1021/acs.joc.8b02389
(2019)Doi:10.1134/S1070363207120031
(2007)Doi:10.1016/S0040-4039(00)77041-9
(1994)Doi:10.1007/BF00901415
(1967)Doi:10.1016/j.ica.2013.12.027
(2014)
