Catalytic enantioselective synthesis of macrolides via asymmetric alkylation

Article abstract of DOI:10.1016/S0957-4166(97)00186-9

Catalytic enantioselective syntheses of the macrolides (R)-(-) phoracantholide and (R)-(+) lasiodiplodin have been achieved. Stereochemistry was introduced in using an arene chromium tricarbonyl derived catalyst, which mediated the enantioselective additi