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Synthesis and biological activity of a 1α,25-dihydroxyvitamin D2 analog bearing an amide group in the side-chain

DOI: 10.1248/cpb.45.185

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 185 - 188 (1997)

Update date:2022-08-03

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Authors:

Konno, KatsuhiroKonno, Katsuhiro

Ojima, KatsujiOjima, Katsuji

Hayashi, TakaakiHayashi, Takaaki

Tanabe, MiyukiTanabe, Miyuki

Takayama, HiroakiTakayama, Hiroaki

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Article abstract of DOI:10.1248/cpb.45.185

Synthesis of a 1α,25-dihydroxyvitamin D2 analog (3), in which the double bond in the side-chain is replaced by an amide group, is described. Condensation of a carboxylic acid (8) with an amine (6) gave an amide (9), which in turn led to 3 via s

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Full text of DOI:10.1248/cpb.45.185

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Product name:(24R)-23-aza-1α,3β-bis[(tert-butyldimethylsilyl)oxy]-22-oxo-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)-6-ergosten-25-ol

Cas No:157769-84-1

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