Discovery of a cyclopentylamine as an orally active dual NK1 receptor antagonist-serotonin reuptake transporter inhibitor

Article abstract of DOI:10.1016/j.bmcl.2014.01.036

Cyclopentylamine 4 was identified as a potent dual NK₁R antagonist-SERT inhibitor. This compound demonstrated significant oral activity in the gerbil forced swimming test, suggesting that dual NK₁R antagonists-SERT inhibitors may be