Tetrahedron Letters p. 2191 - 2194 (1994)
Update date:2022-08-03
Topics:
Hitotsuyanagi, Yukio
Kondo, Kazuyuki
Takeya, Koichi
Itokawa, Hideji
Antitumor cyclic hexapeptide RA-III (2) has been converted to a lactone analogue 3 which is the first analogue of RAs in which the 18-membered macro ring was modified. 3 was found to possess promising antitumor activity, and its solution conformation was established by NMR spectroscopy.
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