Total synthesis of the major metabolites of gomisin A. Synthesis of homochiral met A-II, met A-III, met D, and met F

Article abstract of DOI:10.3987/com-95-s45

The total syntheses of the metabolites of gomisin A (1) were achieved. By the Mukaiyama hydration or the successive double bond migration, lactone ring reduction, glycol formation, and reduction, the homochiral lactones (10a-c) provided met A-III (3), A-II (2), D (5), and F (7).