Design, synthesis, and conformational analysis of a novel macrocyclic HIV- protease inhibitor

DOI: 10.1021/jm00048a004

Source and publish data:

Journal of Medicinal Chemistry p. 3684 - 3692 (1994)

Update date:2022-08-04

Topics: Synthesis Macrocyclic Design Conformational Analysis HIV-Protease Inhibitor

Authors:

Podlogar

Farr Farr

Friedrich

Tarnus Tarnus

Huber Huber

Cregge Cregge

Schirlin

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Article abstract of DOI:10.1021/jm00048a004

Design modifications to the lead HIV-PR inhibitor 1 (MDL 73,669, K(i) = 5 nM) have been postulated based on a computational model of the 1/HIV-PR complex. A novel macrocyclic inhibitor 8 (MDL 104,168) wherein the P₁ and P₃ side chain

Full text of DOI:10.1021/jm00048a004

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