Synthesis and sedative-hypnotic effects of N3-allyl- and N1-allyl- 5,6-substituted 2-thiouracil derivatives in mice

DOI: 10.1248/cpb.46.1370

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Chemical and Pharmaceutical Bulletin p. 1370 - 1373 (1998)

Update date:2022-07-29

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Authors:

Draminski, Marcin

Turski, Krzysztof

Tateoka, Yuji

Kimura, Toshiyuki

Watanabe, Kazuhito

Kondo, Shigemi

Ho, Ing Kang

Yamamoto, Ikuo

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Article abstract of DOI:10.1248/cpb.46.1370

Twenty four thiouracil derivatives, including N³-allyl- (19) and N¹- allyl-2-thiouracil (20) were synthesized and their pharmacological effects [sedative-hypnotic activity (loss of righting reflex and spontaneous activity), convulsan

Full text of DOI:10.1248/cpb.46.1370

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